The antidepressant effect of 4-hydroxybenzyl alcohol 2-naphthoate through monoaminergic,GABAergic system and BDNF signaling pathway

Abstract

Gastrodigenin, also known as 4-hydroxybenzyl alcohol (HBA), is one of the main components of Gastrodia elata, which is a perfect lead compound of natural products. In order to get new active compounds, we modified the structure of HBA through esterification with carboxylic acid, and got a series of derivatives in which 4-hydroxybenzyl alcohol 2-naphthoate (NHBA) showed stronger antidepressant activity than HBA. In this paper, we firstly evaluated the antidepressant activity of NHBA by tail suspension test (TST) and forced swimming test (FST). Then, we carried out the biochemical assay and western blot to determine its mechanism. The results displayed that NHBA could increase the content of serotonin, dopamine, norepinephrine, γ-aminobutyric acid, brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) in mice brain. It suggested that NHBA exhibited an antidepressant-like effect through monoaminergic system, GABAergic system and BDNF/TrkB signaling pathways.     

氩气感应耦合等离子体速度与温度数值模拟

为了获得用于研究再入飞行器热防护系统的感应耦合等离子体风洞流场数据，基于流场、电磁场和化学场的多场耦合建立了非平衡态感应耦合等离子体数值模型。利用该模型对不同入口质量流率和不同工作压力下的感应耦合等离子体进行了数值模拟，得到了相应工作参数下感应耦合等离子体温度与速度的分布特性。计算结果表明：等离子体中心线上的速度随着入口质量流率的增大而增大，而随着工作压力的增大而减小；同时，等离子体中心线上的温度随着入口质量流率的增大而减小，而随着压力的增大先减小后增大。这些结果可为感应耦合等离子体风洞优化设计及其工业应用提供理论指导。     

氮低温制冷循环系统在大科学装置中的应用与发展

大科学装置中低温设备的氮低温冷量需要日益快速增长,为减少能耗和保障装置的长期稳定运行,基于大科学装置氮低温系统运行需求,介绍了氮低温制冷循环系统在国内外大科学装置中的应用情况,总结了目前大科学装置中应用氮低温制冷循环系统的研究现状,并探讨以氮制冷机为核心的氮低温制冷循环系统在未来大科学装置中发展方向。     

Influence of friction and asymmetric freeplay on the limit cycle oscillation in aeroelastic system: An extended Hénon’s technique to temporal integration

Nonlinear effects such as friction and freeplay on the control surfaces can affect aeroelastic dynamics during flight. In particular, these nonlinearities can induce limit cycle oscillations (LCO), changing the system stability, and because of this it is essential to employ computational methods to predict this type of motion during the aircraft development cycle. In this context, the present article presents a matrix notation for describing the Hénon’s method used to reduce errors when considering piecewise linear nonlinearities in the numerical integration process. In addition, a new coordinate system is used to write the aeroelastic system of equations. The proposal defines a displacement vector with generalized and physical variables to simplify the computational implementation of the Hénon’s technique. Additionally, the article discusses the influence of asymmetric freeplay and friction on the LCO of an airfoil with control surface. The results show that the extended Hénon’s technique provides more accurate LCO predictions, that friction can change the frequency and amplitude of these motions, and the asymmetry of freeplay is important to determine the LCO behavior.     

On the combination of kernel principal component analysis and neural networks for process indirect control

ABSTRACT

A new adaptive kernel principal component analysis (KPCA) for non-linear discrete system control is proposed. The proposed approach can be treated as a new proposition for data pre-processing techniques. Indeed, the input vector of neural network controller is pre-processed by the KPCA method. Then, the obtained reduced neural network controller is applied in the indirect adaptive control. The influence of the input data pre-processing on the accuracy of neural network controller results is discussed by using numerical examples of the cases of time-varying parameters of single-input single-output non-linear discrete system and multi-input multi-output system. It is concluded that, using the KPCA method, a significant reduction in the control error and the identification error is obtained. The lowest mean squared error and mean absolute error are shown that the KPCA neural network with the sigmoid kernel function is the best.     

Large monochromatic components in 3‐edge‐colored Steiner triple systems

It is known that in any r‐coloring of the edges of a complete r‐uniform hypergraph, there exists a spanning monochromatic component. Given a Steiner triple system on n vertices, what is the largest monochromatic component one can guarantee in an arbitrary 3‐coloring of the edges? Gyárfás proved that $\left(2n+3\right)/3$ is an absolute lower bound and that this lower bound is best possible for infinitely many $n$. On the other hand, we prove that for almost all Steiner triple systems the lower bound is actually $\left(1?o\left(1\right)\right)n$. We obtain this result as a consequence of a more general theorem which shows that the lower bound depends on the size of a largest 3‐partite hole (ie, disjoint sets $X_1,X_2,X_3$ with $|X_1|=|X_2|=|X_3|$ such that no edge intersects all of $X_1,X_2,X_3$) in the Steiner triple system (Gyárfás previously observed that the upper bound depends on this parameter). Furthermore, we show that this lower bound is tight unless the structure of the Steiner triple system and the coloring of its edges are restricted in a certain way. We also suggest a variety of other Ramsey problems in the setting of Steiner triple systems.     

Global Regularity of the Logarithmically Supercritical MHD System in Two-dimensional Space

In this paper, we study the global regularity of logarithmically supercritical MHD equations in $2$ dimensional, in which the dissipation terms are $-\mu\Lambda^{2\alpha}u$ and $-\nu\mathcal{L}^{2\beta} b$. We show that global regular solutions in the cases $0<\alpha<\frac{1}{2},\beta>1,3\alpha+2\beta>3$.     

三维非连续变形分析方法碰撞分析及其应用

将具有完备动力学理论的非连续变形分析(DDA)方法应用于块体碰撞研究。基于三维DDA(3D DDA)方法,按时步输出块体碰撞过程速度变化和接触嵌入量,进而得到块体碰撞恢复系数、冲量、冲击力。以此为参考指标,采用斜抛、面-面对心等碰撞模型,验证3D DDA方法模拟块体碰撞的有效性,并将3D DDA方法应用于多米诺骨牌倾倒、滚石边坡成灾及防护等算例分析,探讨了多米诺骨牌倾倒机制、滚石启动及运动行为、滚石灾害防护方案。结果表明:多米诺骨牌间距越大,同一块体被碰撞时间越迟,其最终稳定时间也越迟,与下一块体碰撞的动能越大;滚石运动呈侧向平动及转动三维运动特征,每一次碰撞,均引起动能、轨迹或状态的显著变化;滚石拦挡设施弹簧刚度越大,越先达到最大冲击力,最大冲击力随弹簧刚度的增加而减小;可结合树木阻挡效应,耗散滚石动能,降低滚石飞跃高度,使滚石灾害减轻或控制在防护范围以内。     

腔光子-自旋波量子耦合系统中各向异性奇异点的实验研究

通过耦合三维微波腔中光子和腔内钇铁石榴石单晶小球中的自旋波量子形成腔-自旋波量子的耦合系统,并通过精确调节系统参数在该实验系统中观测到各向异性奇异点.奇异点对应于非厄米系统中一种特殊状态,在奇异点处,耦合系统的本征值和本征矢均简并,并且往往伴随着非平庸的物理性质.以往大量研究主要集中在各向同性奇异点的范畴,它的特征是在系统参数空间中沿着不同参数坐标趋近该奇异点时具有相同的函数关系.在这篇文章中,主要介绍实验上在腔光子-自旋波量子耦合系统中通过调节系统的耦合强度和腔的耗散衰减系数两条趋近奇异点的路径而实现了各向异性奇异点,具体分别对应于在趋近奇异点时,本征值的虚部的变化与耦合强度和腔的衰减系数的变化会有线性和平方根不同的行为.各向异性奇异点的实现有助于基于腔光子-自旋波量子耦合系统的量子信息处理和精密探测器件的进一步研究.